Crohn's Disease.

One of my patients came to the office today and she was experience some agressive abdominal symptoms. She was experience a regular episode of Crohn’s Disease.This is a disorder also call regional enteritis is an inflammatory process confined to the mucosa of any or all of the large intestine. Crohn’s is an idiopathic, chronic inflammatory disorder of the bowel usually affects the intestines, but may involve any region of the alimentary tract from the mouth to the anus. Growing evidence suggests that genetic, psychological, inflammatory, intestinal epithelial permeability abnormality factors play significant role in the development of Crohn’s disease and the commensal bacterial flora which appears to be a critical element, particularly in regards to Crohn's disease. In recent years, it has become apparent that overproduction of the Th1 cytokines interleukin-12 and inferferon-γ in Crohn’s disease causes an imbalance between normally occurring positive (immunogenic or inflammatory) responses and negative (tolerogenic or anti-inflammatory) mucosal immune responses. Considerable data indicates that the pathogenesis of Crohn’s disease can be explained by these factors, together with independent environmental triggers such as cigarette smoking.(Pathophysiology of Crohn’s Disease, 2013).I think that is a very interesting information about this disorder. Todays a lot of people suffer this symptoms and we do not even know.